Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment.

Lynn Jeanette SavicIsabel Theresa SchobertDana PetersJohn James WalshFabian Max Laage-GauppCharlie Alexander HammNina TritzLuzie A DoemelMing-De LinAlbert SinusasTodd SchlachterJames S DuncanFahmeed HyderDaniel ComanJulius Chapiro

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

MRSI-based pHe mapping can serve as a longitudinal monitoring tool for viable tumors. As most liver tumors are hyperglycolytic creating microenvironmental acidosis, therapy-induced normalization of tumor pHe may be used as a functional biomarker for positive therapeutic outcome.

Keyphrases

stem cells
high glucose
genome wide
diabetic rats
single cell
gene expression
drug induced