Multiomic analysis reveals cellular and epigenetic plasticity in intestinal pouches of ulcerative colitis patients.

Yu ZhaoRan ZhouBingqing XieCambrian Y LiuMartin KalskiCandace M ChamJason KovalChristopher R WeberDavid T RubinMitch SoginSean CrossonJun HuangAretha FiebigSushila DalalEugene B ChangAnindita BasuSebastian Pott

Published in: medRxiv : the preprint server for health sciences (2023)

UC pouches are characterized by partial colonic metaplasia of the epithelium. These data constitute a resource of transcriptomic and epigenetic signatures of cell populations in the pouch and provide an anchor for understanding the underlying molecular mechanisms of pouchitis.

Keyphrases

ulcerative colitis
end stage renal disease
dna methylation
single cell
gene expression
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
cell therapy
stem cells
rna seq
electronic health record
big data
artificial intelligence
bone marrow
deep learning