Investigation of dual plasmonic core-shell Ag@CuS nanoparticles for potential surface-enhanced Raman spectroscopy-guided photothermal therapy.
Anindita DasVinothini ArunagiriHsieh-Chih TsaiAdhimoorthy PrasannanJuin-Yih LaiPo Da-HongRakesh S MoirangthemPublished in: Nanomedicine (London, England) (2021)
Aim: To prepare efficient metal-semiconductor nanoparticles as noninvasive, real-time imaging probes for photothermal therapy (PTT) applications. Materials & methods: A bottom-up approach was used to fabricate core-shell Ag@CuS nanoparticles (NPs). PTT and Raman mapping were done using HeLa cells. Theoretical simulation of electric field enhancement and heat dissipation density of Ag@CuS NPs was performed. Results: PTT-induced hyperthermia was achieved under 940 nm near-infrared light irradiation. Surface-enhanced Raman spectroscopy (SERS) signals of dye molecules were observed when conjugated with Ag@CuS NPs. Conclusion: Ag@CuS NPs are found to be efficient for SERS imaging and localized heating under laser irradiation, making a promising candidate for SERS-guided PTT.
Keyphrases
- raman spectroscopy
- quantum dots
- highly efficient
- visible light
- high resolution
- cell cycle arrest
- induced apoptosis
- photodynamic therapy
- oxide nanoparticles
- sensitive detection
- gold nanoparticles
- small molecule
- single molecule
- cell death
- radiation therapy
- radiation induced
- cell proliferation
- mass spectrometry
- oxidative stress
- high density
- endothelial cells
- energy transfer
- high speed
- walled carbon nanotubes
- endoplasmic reticulum stress
- label free
- pi k akt
- aqueous solution