A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light.

Marco BlangettiAurore FraixLoretta LazzaratoElisabetta MariniBarbara RolandoFederica SodanoRoberta FrutteroAlberto GascoSalvatore Sortino

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2017)

Using a facile synthetic route, an organic NO release agent based on a BODIPY light-harvesting antenna was devised. This compound is stable in the dark and delivers NO under photoexcitation with biologically favorable green light. Temporally regulated vasodilation capability is demonstrated on rat aorta by green-light-induced NO release.

Keyphrases

nitric oxide
energy transfer
oxidative stress
transcription factor
aortic valve
pulmonary artery
nitric oxide synthase
living cells
pulmonary hypertension
fluorescent probe
highly efficient
water soluble