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A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light.

Marco BlangettiAurore FraixLoretta LazzaratoElisabetta MariniBarbara RolandoFederica SodanoRoberta FrutteroAlberto GascoSalvatore Sortino
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2017)
Using a facile synthetic route, an organic NO release agent based on a BODIPY light-harvesting antenna was devised. This compound is stable in the dark and delivers NO under photoexcitation with biologically favorable green light. Temporally regulated vasodilation capability is demonstrated on rat aorta by green-light-induced NO release.
Keyphrases
  • nitric oxide
  • energy transfer
  • oxidative stress
  • transcription factor
  • aortic valve
  • pulmonary artery
  • nitric oxide synthase
  • living cells
  • pulmonary hypertension
  • fluorescent probe
  • highly efficient
  • water soluble