Single-cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation.
Jie YangHu TanMengjia SunRenzheng ChenZhao JianYuanbin SongJihang ZhangShizhu BianBo ZhangYi ZhangXubin GaoZhen ChenBoji WuXiaowei YeHailin LvZhen LiuLan HuangPublished in: Clinical and translational medicine (2023)
This study highlights the decrease in the anticoagulant status of EECs in LAA as a potential mechanism underlying the propensity for thrombosis, which may aid the development of anticoagulation therapeutic approaches targeting functionally distinct cell subsets or molecules during AF.
Keyphrases
- atrial fibrillation
- left atrial appendage
- single cell
- catheter ablation
- rna seq
- left atrial
- oral anticoagulants
- direct oral anticoagulants
- high throughput
- heart failure
- pulmonary embolism
- percutaneous coronary intervention
- cancer therapy
- peripheral blood
- stem cells
- acute coronary syndrome
- cell therapy
- drug delivery
- climate change
- venous thromboembolism