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Copper oxide nanoparticles suppress retinal angiogenesis via inducing endothelial cell cuproptosis.

Haorui ZhangChang CaiQing LiZheng NieMengzhu WangYongxuan LiuWei ShenHongyuan Song
Published in: Nanomedicine (London, England) (2024)
Background: Copper oxide nanoparticles (CuO NPs) exhibit antitumor activity; however, their potential as an antiangiogenesis agent is unknown. Materials & methods: The antiangiogenesis properties of CuO NPs were evaluated in vitro and in vivo and the underlying mechanism was examined using RNA sequencing and metabolomic analyses. Results: CuO NPs inhibited endothelial cell function in vitro . They also mitigated retinal vasculature development and alleviated pathological retinal angiogenesis in vivo . RNA sequencing and metabolomic analyses revealed that CuO NPs disrupt the tricarboxylic acid cycle and induce cuproptosis, which was further supported by evaluating cuproptosis-related metabolites and proteins. Conclusion: CuO NPs may be an effective antiangiogenic agent for the treatment of retinal angiogenesis.
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