Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single-cell RNA sequencing.

Shiwei HeJunfeng WangYanlei HuangFanyang KongRan YangYong ZhanZifeng LiChunjing YeLingdu MengYankang RenYing ZhouGong ChenZhen ShenSong SunShan Zheng Rui Dong

Published in: Clinical and translational medicine (2023)

This work identifies intestinal fibrosis and related regulators in aganglionic segments of HSCR; hence, anti-fibrotic therapy may be considered to prevent HSCR-associated enterocolitis (HAEC), relieve intestinal stricture and improve cell therapy.

Keyphrases

cell therapy
single cell
rna seq
stem cells
mesenchymal stem cells
high throughput
genome wide
systemic sclerosis
gene expression
liver fibrosis
preterm infants
low birth weight
smoking cessation
drug induced