Effect of macrophage migration inhibitory factor on pulmonary vein arrhythmogenesis through late sodium current.
Chye-Gen ChinYao-Chang ChenYung Kuo LinYen Yu LuWan-Li ChengCheng Chih ChungShih-Ann ChenYi-Jen ChenPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)
Macrophage migration inhibitory factor increased PV arrhythmogenesis through Na+ and Ca2+ dysregulation through the ROS activation of CaMKII signalling, which may contribute to the genesis of AF during inflammation. Anti-CaMKII treatment may reverse PV arrhythmogenesis. Our results clearly reveal a key link between MIF and AF and offer a viable therapeutic target for AF treatment.