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Improving the accuracy of dose estimates from automatically scored dicentric chromosomes by accounting for chromosome number.

David EndesfelderUlrike M KulkaJochen EinbeckUrsula Oestreicher
Published in: International journal of radiation biology (2020)
A major source for the observed overdispersion could be identified, and statistical methods accounting for overdispersion introduced by variations in the number of detected chromosomes were developed, enabling more robust dose estimation and quantification of uncertainties for semi-automatic counting of dicentric chromosomes.
Keyphrases
  • deep learning
  • machine learning
  • copy number
  • dna methylation
  • neural network