5-Methoxytryptophan Alleviates Dextran Sulfate Sodium-Induced Colitis by Inhibiting the Intestinal Epithelial Damage and Inflammatory Response.

Yanling Wang Jun Li Qinyuan Yang Zhenhang Zhu Fang Cheng Xiangyan Ai Yang Liu Dong Bao Zhao Futao Zhao Peng Cheng

Published in: Mediators of inflammation (2024)

5-MTP counteracts excessive inflammation, thereby preventing intestinal epithelial tight junction damage. In addition, inhibition of apoptosis suggests that 5-MTP may be a potential therapeutic agent for colitis.

Keyphrases

oxidative stress
inflammatory response
blood brain barrier
signaling pathway
lipopolysaccharide induced
weight gain
cell death
mouse model
body mass index
ulcerative colitis
immune response
pi k akt