Low glucose enhanced metformin's inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p.

Minglei MaChifa MaPing-Ping LiChunxiao MaFan PingWei LiLingling XuHuabing ZhangQi SunYuxiu Li

Published in: Cell cycle (Georgetown, Tex.) (2020)

PC: pancreatic cancer; DM: diabetes mellitus; PFKFB2: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase2; PFK1: phosphofructokinases; LDH: lactate dehydrogenase; F-2,6-BP: fructose 2,6-bisphosphate.

Keyphrases

glycemic control
blood glucose
tyrosine kinase
protein kinase
stress induced
blood pressure