A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS).
Małgorzata SzczukoMarta Zapalowska-ChwyćRadosław DrozdPublished in: Molecules (Basel, Switzerland) (2019)
Inhibiting the effect of prolactin (by the level of reactive oxygen species) on the activity of GPx3 could be a starting point for the increase in antioxidative stress and the development of the inflammatory state associated with PCOS pathophysiology. Following a low-calorie diet with a lower glycemic index is proposed to silence inflammation by increasing the concentration of uric acid. During GPx3 mobilization, women with PCOS have a higher demand for selenium, and its deficiencies may contribute to disordered thyroid hormone synthesis. The three-month dietary intervention did not silence redox processes in the examined group of women.
Keyphrases
- uric acid
- polycystic ovary syndrome
- metabolic syndrome
- oxidative stress
- reactive oxygen species
- type diabetes
- end stage renal disease
- insulin resistance
- chronic kidney disease
- newly diagnosed
- weight loss
- ejection fraction
- physical activity
- signaling pathway
- prognostic factors
- peritoneal dialysis
- hydrogen peroxide
- nitric oxide
- glycemic control
- anti inflammatory
- pregnancy outcomes
- patient reported