Dynamic DNA methylation of ovaries during pubertal transition in gilts.

Xiaolong YuanShaopan YeZitao ChenXiangchun PanShuwen HuangZhonghui LiYuyi ZhongNing GaoHao ZhangJiaqi LiZhe Zhang

Published in: BMC genomics (2019)

During pubertal transition in gilts, the DNA methylation changes of ovaries were likely to affect the transcription of genes related to PI3K-Akt signaling pathway, GnRH signaling pathway, and Insulin secretion. These observations can provide new insight into the epigenetic mechanism of follicular and sexual maturation during pubertal transition in mammals.

Keyphrases

pi k akt
dna methylation
signaling pathway
genome wide
gene expression
cell cycle arrest
cell proliferation
epithelial mesenchymal transition
induced apoptosis
copy number
mental health
transcription factor
cell death
oxidative stress
bioinformatics analysis