Protective Effects of Gastrodin Against Gentamicin-Induced Vestibular Damage by the Notch Signaling Pathway.

Wen JiangFeifan LiHandong XuMaorong CaoBin XiaoKe GongJingyu MaWeiguo ZhangXuxia TangFenye LiuShudong Yu

Published in: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (2024)

Collectively, these findings underscore the crucial role of gastrodin in safeguarding against gentamicin-induced vestibular dysfunction through the modulation of the Notch signaling pathway. This study suggests the potential of gastrodin as a promising therapeutic agent for preventing vestibular injuries.

Keyphrases

signaling pathway
high glucose
diabetic rats
oxidative stress
pi k akt
epithelial mesenchymal transition
cell proliferation
hearing loss
drug induced
induced apoptosis
endothelial cells
human health
stress induced