Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis.

Dipabarna BhattacharyaJason TheodoropoulosKatariina NurmiTimo JuutilainenKari K EklundRiitta KoivuniemiTiina KelkkaSatu MustjokiTapio Lönnberg

Published in: Molecular medicine (Cambridge, Mass.) (2024)

Our findings suggest that the local environment in the synovium drives the proliferation of activated cytotoxic T cells, and both CD4 + and CD8 + T cells may contribute to tissue destruction and disease pathogenesis.

Keyphrases

single cell
rheumatoid arthritis
rna seq
nk cells
high throughput