Disruption of DNA Repair and Survival Pathways through Heat Shock Protein Inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation Therapy.
Jihong XuPei-Jung WuTzung-Huei LaiPratibha SharmaAlessandro CanellaAlessandra M WelkerChristine E BeattieJ Brad ElderMichelle EasleyRussell LonserNaduparambil K JacobMaciej PietrzakCynthia M TimmersFrederick F LangDeepa SampathVinay K PuduvalliPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
The results of this study demonstrate that targeting HR by HSP90 inhibition sensitizes GSCs to radiation and chemotherapy and extends survival in zebrafish and mouse intracranial models of GBM. These results provide a preclinical rationale for assessment of HSP90 inhibitors in combination with chemoradiation in patients with GBM.