Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease.

Cécile Tissot Joseph TherriaultTharick A PascoalMira ChamounFiroza Z LussierMelissa SavardSulantha S MathotaarachchiAndréa L BenedetEmilie M ThomasMarlee ParsonsZiad NasreddinePedro Rosa-NetoSerge Gauthier

Published in: Alzheimer's & dementia (New York, N. Y.) (2021)

NPS are predominantly related to tau in aging and dementia. Regions affected are part of the behavioral circuits, and vulnerable to early AD pathology. Domain-specific analyses showed NPS are related to the AD pathophysiological processes in a symptom-specific manner.

Keyphrases

mild cognitive impairment
cognitive decline
cerebrospinal fluid
physical activity
depressive symptoms
sleep quality
african american
patient reported