Photochemical fluoro-amino etherification reactions of aryldiazoacetates with NFSI under stoichiometric conditions.
Feifei HeChao PeiRené M KoenigsPublished in: Chemical communications (Cambridge, England) (2019)
Herein, we report on a photochemical three-component reaction of aryldiazoacetates with NFSI and cyclic ethers. This method allows the introduction of both fluorine and a short ether sidechain using 1,4-dioxane as solvent in high yields via an ylide pathway as demonstrated by DFT calculations (26 examples, up to 99% yield).