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MULT1-Encoding DNA Alleviates Schistosomiasis-Associated Hepatic Fibrosis via Modulating Cellular Immune Response.

Lu YangLi SunYalan CaoQi WangAnni SongRu ZhuWenqi LiuShengjun Lu
Published in: Journal of inflammation research (2022)
To the best of our knowledge, we provided the first in vivo evidence that MULT1 is a favorable anti-fibrosis factor in the context of schistosomiasis. The inhibitory effect of MULT1 overexpression on schistosomiasis associated with hepatic fibrosis may result from augmenting the proportion and function of NKG2D-expressing immune cells, and from enhancing NK- and T-cell activation, as well as regulating the helper T (Th)1/Th2 balance.
Keyphrases
  • healthcare
  • cell proliferation
  • nk cells
  • signaling pathway
  • liver fibrosis
  • dendritic cells
  • regulatory t cells
  • transcription factor
  • single molecule
  • cell free