Specific gut pathobionts escape antibody coating and are enriched during flares in patients with severe Crohn's disease.
Carsten EriksenNiels Banhos Danneskiold-SamsøeJanne Marie MollPernille Neve MyersPi W BondegaardSimone VejrumTine Brodka HansenLisbeth Buus RosholmPhilipp RauschKristine Højgaard AllinTine JessKarsten KristiansenJohn PendersDaisy M A E JonkersSusanne B PedersenPublished in: Gut (2023)
Distinct gut bacterial IgG2-coating was demonstrated in patients with severe CD and during disease flares. Co-occurrence of non-coated pathobionts with IgG2-coated bacteria points to an uncontrolled inflammatory condition in severe CD mediated via escape from antibody coating by two gut pathobionts.