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Prognostic Factors and Resectability Predictors in Insular Gliomas: A Systematic Review.

Ariadni PapadopoulouNiraj S Kumar
Published in: Journal of neurological surgery. Part A, Central European neurosurgery (2023)
 Negative prognosticators reported in ≥2 studies included putaminal or paralimbic involvement and higher tumor grade, while seizures at presentation, isocitrate dehydrogenase (IDH) mutation, increased extent of resection, and higher Karnofsky Performance Status preoperatively and at 3 months postoperation were positive prognosticators. Resectability predictors reported in ≥2 studies included the positive predictors of zone I/zone IV tumor location and intraoperative imaging use and the negative predictor of encased lenticulostriate arteries. Paralimbic INGs are not a single entity with homogeneous prognosis. Integration of identified prognosticators in a prospective trial to devise a grading system for INGs can improve clinical decision-making.
Keyphrases
  • prognostic factors
  • decision making
  • high resolution
  • case control
  • clinical trial
  • study protocol
  • patients undergoing
  • low grade
  • phase iii
  • mass spectrometry
  • wild type