Methanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis.
Faris A AlrumaihiMasood Alam KhanKhaled S AllemailemMohammed A AlsahliAhmad Abdulaziz A AlmatroudiHina YounusSultan A AlsuhaibaniMohammad AlgahtaniArif KhanPublished in: Journal of inflammation research (2021)
This study, for the first time, reports the mechanistic details of the anti-cancer potential of FSE. It requires a detailed analysis to understand the effect of FSE to induce the apoptosis through the multiple signaling pathways at varying concentrations. The nontoxic effect of FSE in mice suggests to utilize it safely for pharmaceutical formulations in different cancer systems.
Keyphrases
- oxidative stress
- endoplasmic reticulum stress
- cell cycle arrest
- breast cancer cells
- cell death
- signaling pathway
- papillary thyroid
- pi k akt
- induced apoptosis
- cell cycle
- squamous cell
- type diabetes
- epithelial mesenchymal transition
- high fat diet induced
- adipose tissue
- emergency department
- cell proliferation
- adverse drug