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Transactivation of the estrogen receptor promoter by BRCA1.

William B ArcheyBradley A Arrick
Published in: Cancer cell international (2017)
The work described here, along with previously published work, indicates that activity of certain transcriptional regulatory elements and CpG methylation both represent important mechanisms by which the ER gene is typically inactive in breast cancers associated with BRCA1 mutations. The absence of ER in these breast cancers has significant implications for pathogenesis, prevention, and treatment.
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