Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR.

Sophie LauNaomi StanhopeJohn M GriffinEleri HughesDavid A Middleton

Published in: Chemical communications (Cambridge, England) (2019)

NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.

Keyphrases

solid state
high density
low density lipoprotein
cardiovascular disease
coronary artery disease
drug delivery
positron emission tomography
cancer therapy
walled carbon nanotubes
drug induced
single molecule
computed tomography
type diabetes
pet imaging
mass spectrometry
wound healing
pet ct