GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.
Nikhil R GandasiRui GaoLakshmi KothegalaAbigail PearceCristiano SantosSamuel AcremanDavide BascoAnna BenrickMargarita V ChibalinaAnne ClarkClaudia GuidaMatthew HarrisPaul R V JohnsonJakob G KnudsenJinfang MaCaroline MirandaMakoto ShigetoAndrei I TarasovHo Yan YeungBernard ThorensIngrid Wernstedt AsterholmQuan ZhangReshma D RamracheyaGraham LaddsPatrik RorsmanPublished in: Diabetologia (2023)
We conclude that the GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of glucagon secretion. We propose that the increase in circulating glucagon observed following genetic/pharmacological inactivation of glucagon signalling in mice and in people with type 2 diabetes reflects the removal of GLP-1(9-36)'s glucagonostatic action.