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Mutational signatures in colon cancer.

Priyatama PandeyZhi YangDarryl ShibataPaul MarjoramKimberly D Siegmund
Published in: BMC research notes (2019)
We apply a probabilistic mutation signature model to somatic mutations previously reported for six adult normal colon stem cells and 431 colon adenocarcinomas. We infer six mutational signatures in colon cancer, four being specific to tumors with hypermutation. Just two signatures explained the majority of mutations in the small number of normal aging colon samples. All six signatures are independently identified in a series of 295 Chinese colorectal cancers.
Keyphrases
  • stem cells
  • genome wide
  • copy number
  • mesenchymal stem cells
  • young adults
  • squamous cell