Hybrid spheroids containing mesenchymal stem cells promote therapeutic angiogenesis by increasing engraftment of co-transplanted endothelial colony-forming cells in vivo.

Young Cheol SongGyu Tae ParkHye Ji MoonEun-Bae ChoiMi-Ju LimJung Won YoonNayeon LeeSang Mo KwonByung-Joo LeeJae-Ho Kim

Published in: Stem cell research & therapy (2023)

These results suggest that hybrid spheroids containing MSCs can serve as carriers for cell transplantation of ECFCs which have poor in vivo engraftment efficiency.

Keyphrases

mesenchymal stem cells
cell therapy
umbilical cord
endothelial cells
induced apoptosis
cell cycle arrest
single cell
hematopoietic stem cell
bone marrow
vascular endothelial growth factor
stem cells
cell death
cell proliferation
oxidative stress
pi k akt