Low and Highly Variable Exposure to Prophylactic LMWH Nadroparin in Critically Ill Patients: Back to the Drawing Board for Prophylactic Dosing?

Jeroen Diepstraten Anne van RongenMarianne P ZijlstraMarieke J H A KruipPim L J van der HeidenRob Ter Heine

Published in: Clinical pharmacokinetics (2022)

Low exposure and highly variable pharmacokinetics of nadroparin were observed in intensive care unit patients treated with a prophylactic dose. It can be debated whether nadroparin is currently dosed optimally in intensive care unit patients and our findings encourage the investigation of higher and tailored dosing of nadroparin in the critically ill.

Keyphrases

intensive care unit
end stage renal disease
ejection fraction
newly diagnosed
mechanical ventilation
chronic kidney disease
peritoneal dialysis
patient reported outcomes
smoking cessation