WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells.
Juan Manuel Iglesias-PedrazDiego Matia Fossatti-JaraValeria Valle-Riestra-FeliceSergio Rafael Cruz-VisalayaJose Antonio Ayala FelixLucio ComaiPublished in: BMC molecular and cell biology (2020)
Our findings suggest that WRN influences the export of mRNAs from the nucleus through its interaction with the NXF1 export receptor thereby affecting cellular proteostasis. In summary, we identified a new partner and a novel function of WRN, which is especially important for the proliferation of cancer cells.