FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis.

Liwei LangYuanping XiongNestor Prieto-DominguezReid LovelessCaleb JensenChloe ShayYong Teng

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our study gains novel mechanistic insights into melatonin-mediated modulation of FGF19/FGFR4 signaling in HNSCC, demonstrating that activating this molecular node confines the role of melatonin in suppressing metastasis and even triggers the switch of its function from anti-metastasis to metastasis promotion. The blockade of FGF19/FGFR4 signaling would have great potential in improving the efficacy of melatonin supplements in cancer treatment.

Keyphrases

signaling pathway
lymph node
risk assessment
climate change
human health