ISSLS PRIZE in Basic Science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain.
Luca AmbrosioJordy ScholClara Ruiz-FernándezShota TamagawaHazuki SomaVeronica TilottaGiuseppina Di GiacomoClaudia CicioneShunya NakayamaKosuke KamiyaRocco PapaliaMasato SatoGianluca VadalàMasahiko WatanabeVincenzo DenaroDaisuke SakaiPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2024)
-EVs, surpassing MSC-derived counterparts. These findings raise questions about the validity of MSCs as both EV sources and cellular therapeutics against IDD. The study emphasizes the critical influence of cell type, source, and culture conditions in EV-based therapeutics.