MicroRNA-223 negatively regulates LPS-induced inflammatory responses by targeting NLRP3 in human dental pulp fibroblasts.

D WangS SunY XueJ QiuT YeR ZhangB SongWenxi HeY ZhangWenkai Jiang

Published in: International endodontic journal (2020)

MiR-223 served as a negative regulator involved in the control of the production and secretion of proinflammatory cytokines mediated by the NLRP3/CASP1 inflammasome pathway by targeting NLRP3. These data provide insight into the potential regulatory effects of miRNAs on the NLRP3 inflammasome, thus opening up novel potential therapeutic avenues for future endodontic treatment.

Keyphrases

nlrp inflammasome
lps induced
inflammatory response
endothelial cells
transcription factor
cell proliferation
long non coding rna
electronic health record
current status
risk assessment
climate change
replacement therapy
deep learning