Does Xpert® MTB/RIF assay give rifampicin resistance results without identified mutation? Review of cases from Addis Ababa, Ethiopia.

Ayinalem AlemuMengistu TadesseGetachew SeidHelina MollalignKirubel EshetuWaganeh SinshawYeshiwork AbebawMisikir AmareBiniyam DagneGetu DiribaBazezew YenewMelak GetuBetselot Zerihun

Published in: BMC infectious diseases (2020)

Mutations associated with Probe E (codons 529-533) region were identified as the commonest rpoB gene mutations. The Rifampicin resistance results found without any identified missing probe needs further study. The lower DNA amount was observed in extrapulmonary specimens compared with sputum.

Keyphrases

pulmonary tuberculosis
mycobacterium tuberculosis
living cells
quantum dots
single molecule
high throughput
cystic fibrosis
cell free
fine needle aspiration