Performance of the pattern-based interpretation of p53 immunohistochemistry as a surrogate for TP53 mutations in vulvar squamous cell carcinoma.
Kim E KortekaasNienke Solleveld-WesterinkBasile Tessier-CloutierTessa A RuttenMariëtte I E PoelgeestC Blake GilksLien N HoangTjalling BossePublished in: Histopathology (2020)
Pattern-based p53 IHC classification is highly reproducible among experienced gynaecological pathologists and accurately reflects TP53 mutations in VSCC. This approach to p53 IHC interpretation offers guidance and provides necessary clarity for resolving the proposed prognostic relevance of final p53 IHC class within HPV-independent VSCC.