Systemic and local evidence for complement involvement in chronic spontaneous urticaria.
Mehran Alizadeh AghdamMignon van den ElzenHarmieke van Os-MedendorpMarijke R van DijkEdward F KnolAndré C KnulstHeike RöckmannHenny G OttenPublished in: Clinical and translational allergy (2021)
Both C4d deposition in lesional skin and elevated C5a levels in peripheral blood indicate the involvement of complement activation in the pathogenesis of CSU. No correlation was found between omalizumab and activation of complement indicative of independent processes in the immunopathogenesis of CSU.
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