Concomitant experimental coinfection by Plasmodium berghei NK65-NY and Ascaris suum downregulates the Ascaris-specific immune response and potentiates Ascaris-associated lung pathology.
Flaviane Vieira-SantosThaís Leal-SilvaLuiza de Lima Silva PadrãoAna Cristina Loiola RuasDenise Silva NogueiraLucas KraemerFabrício Marcus Silva OliveiraMarcelo Vidigal CaliariRemo Castro RussoRicardo Toshio FujiwaraLilian Lacerda BuenoPublished in: Malaria journal (2021)
This study demonstrates that the Ascaris-Plasmodium interaction is harmful to the host and suggests that this coinfection may potentiate Ascaris-associated pathology by dampening the Ascaris-specific immune response, resulting in the early death of affected animals.