Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.
Michal ZapotockyKiran BeeraJenny AdamskiNormand LaperierreSharon GugerLaura JanzenAlvaro LassalettaLiana Figueiredo NobreUte BartelsUri TaboriCynthia HawkinsStacey UrbachDerek S TsangPeter B DirksMichael D TaylorEric BouffetDonald J MabbottVijay RamsawamiPublished in: Cancer (2019)
Data from a molecularly informed large cohort of patients with PFE clearly indicate improved survival over time, related to more aggressive surgery and upfront radiotherapy. However, to the best of the authors' knowledge, the current study is the first, in a subgrouped cohort, to demonstrate that this approach results in reduced neurocognitive outcomes over time.