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Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension.

Xiaoyu SunShunxiong TangBinbin HouZhijun DuanZhen LiuYang LiShoucheng HeQiuming WangQingyong Chang
Published in: BMC gastroenterology (2021)
Inhibition of P-gp, MRP2, and CYP3A4 might represent a valid option for decreasing intestinal first-pass effects on orally administered OCT, thereby increasing its bioavailability to alleviate PH in patients with cirrhosis.
Keyphrases
  • blood pressure
  • cell proliferation
  • diabetic retinopathy
  • neuroendocrine tumors