Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension.
Xiaoyu SunShunxiong TangBinbin HouZhijun DuanZhen LiuYang LiShoucheng HeQiuming WangQingyong ChangPublished in: BMC gastroenterology (2021)
Inhibition of P-gp, MRP2, and CYP3A4 might represent a valid option for decreasing intestinal first-pass effects on orally administered OCT, thereby increasing its bioavailability to alleviate PH in patients with cirrhosis.