Relationships Between Type 2 Diabetes, Neuropathy, and Microvascular Dysfunction: Evidence From Patients With Cryptogenic Axonal Polyneuropathy.
Anna L EmanuelMariska D NieuwenhoffErica S KlaassenAjay VermaMark H H KramerRob StrijersAlexander F J E VranckenEtto EringaGeert Jan GroeneveldErik H SernéPublished in: Diabetes care (2017)
In this study, endothelium-dependent vasodilation was reduced in patients with type 2 diabetes regardless of the presence of polyneuropathy, whereas microvascular vasodilation was normal in patients with CAP. These data suggest that in type 2 diabetes, neuropathy does not contribute to impaired microvascular endothelium-dependent vasodilation and vice versa. In addition, this study suggests that impaired microvascular vasodilation does not contribute to CAP.