The inhibitory effects of compound Muniziqi granule against B16 cells and harmine induced autophagy and apoptosis by inhibiting Akt/mTOR pathway.

Nan ZouYue WeiFenghua LiYang YangXuemei ChengChang-Hong Wang

Published in: BMC complementary and alternative medicine (2017)

Harmine could induce autophagy and apoptosis by inhibiting Akt/mTOR pathway in B16 cells. Harmine might be a promising therapeutic agent for treatment of melanoma in MNZQ.

Keyphrases

signaling pathway
endoplasmic reticulum stress
cell cycle arrest
pi k akt
cell death
oxidative stress
cell proliferation
diabetic rats
high glucose
drug induced
endothelial cells
stress induced