Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058.
So-Ichiro KimuraYoshihiro WatanabeYudai MikasaRei MiyanoToshiyuki TokiwaKenichi NonakaTakuji NakashimaYoshihiko NoguchiTomoyasu HiroseToshiaki SunazukaRei HokariAki IshiyamaMasato IwatsukiPublished in: The Journal of antibiotics (2024)
Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.
Keyphrases
- ms ms
- high resolution
- molecular docking
- mass spectrometry
- magnetic resonance
- multiple sclerosis
- high performance liquid chromatography
- liquid chromatography
- liquid chromatography tandem mass spectrometry
- endothelial cells
- high intensity
- simultaneous determination
- gas chromatography
- solid state
- tandem mass spectrometry