Improved, Efficient, and Simple Methodology for the Resolution of Racemic Benoxaprofen: A Nonsteroidal Anti-Inflammatory Drug (NSAID).

The present article discloses an improved, efficient, and simple resolution methodology for the preparation of (S)-benoxaprofen which is a nonsteroidal anti-inflammatory drug (NSAID). The resolution of racemic benoxaprofen uses an easily available, efficient, recoverable, and cost-effective chiral reagent, namely, (1R,2S)-(+)-cis-1-amino-2-indanol. This novel resolution process is having a very high purity of (S)-benoxaprofen, greater than 99%, substantially free from (R)-benoxaprofen (less than 1%).