Donor Macrophages Modulate Rejection After Heart Transplantation.
Benjamin J KopeckyHao DunJunedh M AmruteChieh-Yu LinAndrea L BredemeyerYuriko TeradaPeter O BayguinovAndrew L KoenigChristian Corbin FryeJames A J FitzpatrickDaniel KreiselKory J LavinePublished in: Circulation (2022)
macrophages are key mediators of allograft rejection, and deletion of MYD88 signaling in donor macrophages is sufficient to suppress rejection and extend allograft survival. This highlights the therapeutic potential of donor heart-based interventions.