Electron transfer dissociation of synthetic and natural peptides containing lanthionine/methyllanthionine bridges.

Ashwini B DolleNarasimhappagari JagadeeshSuman BhaumikSunita PrakashHimansu S Biswal Konkallu Hanumae Gowd

Published in: Rapid communications in mass spectrometry : RCM (2018)

ETD successfully cleaves the lanthionine/methyllanthionine bridges of synthetic and natural lantipeptides. Diagnostic fragment ions of ETD cleavage of lanthionine/methyllanthionine bridges are the N-terminal cysteine/methylcysteine thiyl radical and C-terminal dehydroalanine. Detection of the cysteine/methylcysteine thiyl radical and dehydroalanine in combined ETD-CID-MS may be used for the rapid identification of lantipeptide natural products.

Keyphrases

electron transfer
loop mediated isothermal amplification
fluorescent probe
living cells
mass spectrometry
multiple sclerosis
ms ms
sensitive detection