Login / Signup

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination.

David PejoskiCasimir de RhamPaola Martinez-MurilloFrancesco SantoroFloriane AudersetDonata MedagliniGianni PozziMaria VonoPaul-Henri LambertAngela HuttnerMariëlle C HaksTom H M OttenhoffJean VillardClaire-Anne Siegristnull nullnull nullnull null
Published in: NPJ vaccines (2020)
The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.
Keyphrases
  • nk cells
  • immune response
  • endothelial cells
  • single cell
  • stem cells
  • dendritic cells
  • cancer therapy
  • binding protein
  • natural killer cells