Natural killers shed attachments to kill again.

Published in: The Journal of cell biology (2018)

Natural killer cells target antibody-bound cells following engagement of the Fc receptor CD16. Srpan et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201712085) reveal that activation-induced shedding of CD16 leads to more motile behavior, allowing more targets to be engaged and killed in a given time.

Keyphrases

natural killer cells
single cell
induced apoptosis
cell cycle arrest
high glucose
nk cells
diabetic rats
oxidative stress
drug induced
endothelial cells
cell death
endoplasmic reticulum stress
dna methylation
signaling pathway
cell proliferation
mesenchymal stem cells