Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation.

Chenyang HanHeping ShenYi YangYongjia ShengJin WangWenyan LiXiaohong ZhouLi GuoLiping ZhaiQiaobing Guan

Published in: Brain and behavior (2020)

Our study validated that 6-OHDA could induce apoptosis of dopaminergic neurons via ROS-NLRP3 activation. ACP could inhibit this signal and protect dopaminergic neurons, which might be promising in research of PD therapeutics.

Keyphrases

cell death
oxidative stress
dna damage
spinal cord
reactive oxygen species
diabetic rats
high glucose
signaling pathway
endoplasmic reticulum stress
nlrp inflammasome
small molecule
endothelial cells
cerebral ischemia
subarachnoid hemorrhage
blood brain barrier
stress induced