Modulation of heroin intake by ovarian hormones in gonadectomized and intact female rats.

Mark A SmithSarah B EthridgeTallia PearsonHuailin ZhangMadison M MarcusShannon L BallardAlexander T CasimirKenzie M PotterKarl T SchmidtJessica L SharpAndrea M Robinson

Published in: Psychopharmacology (2021)

These data suggest that (1) estradiol but not progesterone is responsible for proestrus-associated decreases in heroin intake and (2) estradiol decreases heroin intake relative to progesterone. These data differ from those reported previously with stimulants and suggest that estrogen-based pharmacotherapies may be of value to women with opioid use disorder.

Keyphrases

estrogen receptor
electronic health record
weight gain
big data
machine learning
deep learning