SSPH I, A Novel Anti-cancer Saponin, Inhibits EMT and Invasion and Migration of NSCLC by Suppressing MAPK/ERK1/2 and PI3K/AKT/ mTOR Signaling Pathways.

Jinling ZhouJian LuoRizhi GanLimin ZhiHuan ZhouMeixian LvYinmei HuangGang Liang

Published in: Recent patents on anti-cancer drug discovery (2024)

SSPH I inhibited EMT, migration, and invasion of NSCLC cells by suppressing MAPK/ERK1/2 and PI3K/AKT/mTOR signaling pathways, suggesting that the natural compound SSPH I could be used for inhibiting metastasis of NSCLC.

Keyphrases

signaling pathway
induced apoptosis
epithelial mesenchymal transition
small cell lung cancer
pi k akt
cell cycle arrest
advanced non small cell lung cancer
brain metastases
cell proliferation
endoplasmic reticulum stress
cell death