Modulation of non-steroidal anti-inflammatory drug-induced, ER stress-mediated apoptosis in Caco-2 cells by different polyphenolic antioxidants: a mechanistic study.

Cherdsak BoonyongNontima Vardhanabhuti Suree Jianmongkol

Published in: The Journal of pharmacy and pharmacology (2020)

Epigallocatechin gallate, phyllanthin and hypophyllanthin displayed different effects in the ER stress-mediated apoptosis, depending upon their interaction with the specific unfolded protein response signalling.

Keyphrases

drug induced
liver injury
anti inflammatory
induced apoptosis
cell cycle arrest
adverse drug
anti inflammatory drugs
signaling pathway
oxidative stress
endoplasmic reticulum